Tag

Insulin

45 genetic variants with this tag.

RSID	Gene	Description	Category
rs2479106	DENND1A	Intronic variant in the androgen-regulating DENND1A gene associated with poly...	Fertility & Reproductive Health	PCOS Fertility Reproductive Health	Strong
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Energy & Weight	Diabetes Fat Metabolism Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Energy & Weight	Diabetes Insulin Fat Metabolism	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Energy & Weight	Diabetes Insulin Diet	Established
rs5219	KCNJ11 E23K	Controls the pancreatic beta-cell potassium channel that regulates insulin se...	Energy & Weight	Diabetes Insulin Metabolic	Strong
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Energy & Weight	Zinc Insulin Diabetes	Established
rs1799883	FABP2 Ala54Thr	Intestinal fat absorption - affects how efficiently you absorb dietary fat	Lipid & Fat Metabolism	Fat Metabolism Diet Insulin	Moderate
rs2295080	MTOR	Promoter variant that reduces mTOR expression; the G allele lowers mTOR trans...	Longevity & Aging	Longevity Aging Autophagy	Moderate
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Energy & Weight	Diabetes Insulin Cardiovascular	Strong
rs10423928	GIPR	Intronic GIPR variant that reduces functional GIP receptor expression via alt...	Energy & Weight	Diabetes Insulin Diet	Strong
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Energy & Weight	Appetite Obesity Metabolic	Strong
rs2229765	IGF1R c.3179G>A (E1013E)	Synonymous IGF1R variant associated with lower circulating IGF-1 levels and e...	Longevity & Aging	Longevity Insulin Growth Factors	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Energy & Weight	Obesity Appetite Diet	Moderate
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs1776897	HMGA1	Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an...	Lipid & Fat Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2542052	APOC3	Promoter variant that reduces APOC3 expression, associated with lower triglyc...	Longevity & Aging	Longevity Triglycerides Cardiovascular	Strong
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Energy & Weight	Fat Metabolism Obesity Insulin	Moderate
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Energy & Weight	Obesity Appetite Metabolic Syndrome	Moderate
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Energy & Weight	Nutrition & Metabolism Insulin Diabetes	Strong
rs1991517	TSHR Asp727Glu	Affects TSH receptor sensitivity and thyroid hormone regulation; influences T...	Hormones & Sleep	Hormones & Thyroid Thyroid Metabolism	Strong
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Energy & Weight	Fat Metabolism Obesity Insulin	Moderate
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Energy & Weight	Fat Metabolism Obesity Diet	Moderate
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Heart & Inflammation	Cardiovascular Diabetes Insulin	Moderate
rs1800849	UCP3 -55C>T	Promoter variant in skeletal muscle uncoupling protein 3 that increases UCP3 ...	Energy & Weight	Fat Metabolism Diabetes Insulin	Moderate
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs2241766	ADIPOQ T45G	Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability...	Heart & Inflammation	Fat Metabolism Obesity Insulin	Moderate
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Energy & Weight	Fat Metabolism Obesity Diet	Moderate
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Energy & Weight	Obesity Fat Metabolism Diet	Moderate
rs10195252	GRB14/COBLL1	Intergenic variant between GRB14 and COBLL1 that acts as an eQTL for GRB14 in...	Energy & Weight	Fat Metabolism Insulin Lipedema	Strong
rs6905288	VEGFA	Adipose tissue vascularization variant near VEGFA influencing fat distributio...	Heart & Inflammation	Fat Metabolism Cardiovascular Insulin	Moderate
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian Sleep Diabetes	Strong
rs3803304	AKT1	Intronic AKT1 variant near a conserved exon-intron boundary; the G allele is ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Energy & Weight	Fat Metabolism Obesity Diet	Strong
rs11212617	ATM	Intronic variant near the ATM gene affecting metformin's activation of AMPK; ...	Longevity & Aging	Longevity Aging DNA Repair	Moderate
rs10305492	GLP1R A316T	Rare protective missense variant in the GLP-1 receptor associated with lower ...	Pharmacogenomics	Drug Metabolism Diabetes Insulin	Strong
rs12206094	FOXO3	Functional FOXO3 intronic variant with allele-specific CTCF binding and IGF-1...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs5068	NPPA	3'UTR variant that disrupts miR-425 binding, increasing atrial natriuretic pe...	Heart & Inflammation	Cardiovascular Blood Pressure Hypertension	Strong
rs1053049	PPARD 3'UTR variant	3'UTR variant in PPARD that acts as the third tag in the elite athlete haplot...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs6902123	PPARD	Intronic PPARD variant that independently impairs hepatic fat mobilization du...	Fitness & Body	Fat Metabolism Exercise Liver	Moderate