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rs9939609
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FTO
Intron 1 T>A
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The most strongly replicated obesity-associated variant, affecting body weigh...
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Energy & Weight
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Established
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rs17782313
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MC4R
Near-gene C>T
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Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...
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Energy & Weight
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Strong
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rs1042571
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POMC
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3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...
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Energy & Weight
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Moderate
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rs16147
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NPY
C-399T
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Promoter variant in neuropeptide Y that modulates NPY expression under stress...
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Mood & Behavior
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Moderate
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rs696217
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GHRL
Leu72Met
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Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...
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Energy & Weight
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Moderate
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rs1137101
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LEPR
Q223R (Gln223Arg)
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Common leptin receptor variant in the leptin-binding domain affecting satiety...
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Hormones & Sleep
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Moderate
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rs6548238
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TMEM18
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Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...
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Energy & Weight
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Strong
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rs2815752
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NEGR1
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Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...
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Energy & Weight
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Strong
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rs1841499
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NEGR1
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Hypothalamic appetite regulator variant linking obesity susceptibility to mig...
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Energy & Weight
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Moderate
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rs11172113
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LRP1
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Intronic enhancer variant in LRP1 that regulates receptor expression in brain...
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Energy & Weight
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Moderate
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rs29941
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KCTD15
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GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...
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Energy & Weight
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Moderate
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rs7647305
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ETV5
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GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...
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Energy & Weight
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Moderate
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rs10767664
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BDNF
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Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...
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Energy & Weight
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Strong
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rs10150332
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NRXN3
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Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...
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Energy & Weight
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Strong
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