Tag

Diabetes

50 genetic variants with this tag.

RSID	Gene	Description	Category
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Longevity Aging Cardiovascular	Established
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Energy & Weight	Diabetes Fat Metabolism Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Energy & Weight	Diabetes Insulin Fat Metabolism	Strong
rs1799941	SHBG	Promoter region variant affecting sex hormone-binding globulin levels, with t...	Hormones & Sleep	Hormones & Thyroid Cardiovascular Diabetes	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Energy & Weight	Diabetes Insulin Diet	Established
rs5219	KCNJ11 E23K	Controls the pancreatic beta-cell potassium channel that regulates insulin se...	Energy & Weight	Diabetes Insulin Metabolic	Strong
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Energy & Weight	Zinc Insulin Diabetes	Established
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Energy & Weight	Diabetes Insulin Cardiovascular	Strong
rs3087243	CTLA4 CT60	Immune checkpoint regulatory variant in the 3'UTR affecting T-cell activation...	Immune & Gut	Immune & Autoimmune Thyroid Diabetes	Strong
rs10423928	GIPR	Intronic GIPR variant that reduces functional GIP receptor expression via alt...	Energy & Weight	Diabetes Insulin Diet	Strong
rs1205	CRP +1846C>T	3' UTR variant that modulates baseline C-reactive protein levels and inflamma...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Strong
rs1800795	IL6 -174G/C	Promoter variant controlling interleukin-6 expression — affects inflammation,...	Fitness & Body	Inflammation Cardiovascular Fitness	Strong
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Energy & Weight	Obesity Metabolic Diabetes	Established
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Energy & Weight	Appetite Obesity Metabolic	Strong
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Energy & Weight	Obesity Appetite Metabolic Syndrome	Moderate
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Lipid & Fat Metabolism	Fat Metabolism Triglycerides Diet	Established
rs1862513	RETN -420C>G	Promoter variant that increases resistin expression via Sp1/Sp3 transcription...	Energy & Weight	Nutrition & Metabolism Insulin Resistance Inflammation	Moderate
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Energy & Weight	Nutrition & Metabolism Insulin Diabetes	Strong
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs8192678	PPARGC1A Gly482Ser	Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha...	Longevity & Aging	Fitness Endurance Diabetes	Strong
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Energy & Weight	Fat Metabolism Obesity Insulin	Moderate
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Energy & Weight	Fat Metabolism Obesity Diet	Moderate
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Heart & Inflammation	Cardiovascular Diabetes Insulin	Moderate
rs1800849	UCP3 -55C>T	Promoter variant in skeletal muscle uncoupling protein 3 that increases UCP3 ...	Energy & Weight	Fat Metabolism Diabetes Insulin	Moderate
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Nutrition & Metabolism Obesity Diabetes	Moderate
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Longevity Aging Cardiovascular	Strong
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs11590235	SKI	TGF-beta signaling regulator variant identified as the top shared locus betwe...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Moderate
rs10195252	GRB14/COBLL1	Intergenic variant between GRB14 and COBLL1 that acts as an eQTL for GRB14 in...	Energy & Weight	Fat Metabolism Insulin Lipedema	Strong
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian Sleep Diabetes	Strong
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs16847897	TERC	Regulatory variant at the TERC locus associated with shorter telomeres and ac...	Longevity & Aging	Telomere Biology Aging Longevity	Strong
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Energy & Weight	Obesity Appetite Fat Metabolism	Strong
rs11212617	ATM	Intronic variant near the ATM gene affecting metformin's activation of AMPK; ...	Longevity & Aging	Longevity Aging DNA Repair	Moderate
rs6923761	GLP1R Gly168Ser	GLP-1 receptor variant that alters response to GLP-1 agonist medications used...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Energy & Weight	Obesity Appetite Diabetes	Moderate
rs3765467	GLP1R Arg131Gln	Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs10305492	GLP1R A316T	Rare protective missense variant in the GLP-1 receptor associated with lower ...	Pharmacogenomics	Drug Metabolism Diabetes Insulin	Strong
rs1042044	GLP1R Leu260Phe	GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e...	Pharmacogenomics	Drug Response Pharmacogenomics Obesity	Moderate
rs6947337	INHBA	Activin A signaling variant near INHBA linking adipocyte dysfunction to share...	Energy & Weight	Obesity Fat Metabolism Inflammation	Moderate
rs622342	SLC22A1 A>C	Intronic variant in the OCT1 organic cation transporter reducing hepatic metf...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Diabetes	Moderate
rs2289669	SLC47A1 MATE1 G-1853A	Intronic variant in MATE1, the renal and hepatic metformin efflux transporter...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Diabetes	Moderate
rs17697419	VEGFC	Intronic variant in the primary lymphangiogenesis growth factor gene; the min...	Heart & Inflammation	Cardiovascular Diabetes Inflammation	Moderate
rs316019	SLC22A2 Ala270Ser	Reduces OCT2 organic cation transporter function in the kidney, lowering metf...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Diabetes	Moderate
rs17697515	VEGFC	Intronic VEGFC variant independently associated with reduced diabetic retinop...	Heart & Inflammation	Cardiovascular Inflammation Diabetes	Moderate
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Energy & Weight	Obesity Metabolic Fat Metabolism	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Energy & Weight	Obesity Leptin Insulin Resistance	Strong
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Energy & Weight	Obesity Satiety Appetite	Strong
rs116862713	PRKAB1	Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig...	Vitamins & Micronutrients	Diabetes Insulin Resistance Energy Metabolism	Emerging