Tag

Liver Health

14 genetic variants with this tag.

RSID	Gene	Description	Category
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Lipid & Fat Metabolism	Fat Metabolism Triglycerides Diet	Established
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Lipid & Fat Metabolism	Metabolic Cardiovascular Cholesterol	Strong
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Triglycerides	Strong
rs72613567	HSD17B13 Splice Variant (;A)	Protective adenine insertion disrupting the HSD17B13 splice donor site, produ...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Alcohol	Established
rs6834314	HSD17B13	Intergenic tag SNP in near-perfect linkage disequilibrium with the HSD17B13 s...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Liver Disease	Moderate
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Cholesterol	Established
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs4148323	UGT1A1 *6 Gly71Arg	Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc...	Pharmacogenomics	Pharmacogenomics Drug Metabolism Chemotherapy	Established
rs1229984	ADH1B His48Arg	ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r...	Mood & Behavior	Addiction Alcohol Cancer Risk	Established
rs2066702	ADH1B Arg370Cys	ADH1B*3 variant encoding a superactive alcohol dehydrogenase found almost exc...	Mood & Behavior	Addiction Alcohol Detoxification	Strong
rs1693482	ADH1C Arg272Gln (ADH1C1/2)	ADH1C variant defining the fast (ADH1C1, Arg272) vs slow (ADH1C2, Gln272) a...	Mood & Behavior	Addiction Alcohol Cancer Risk	Strong
rs17147230	IL6	Near-gene upstream variant in IL6 associated with hepatocellular carcinoma ri...	Longevity & Aging	Inflammation Longevity Liver Health	Moderate