|
rs5219
|
KCNJ11
E23K
|
Controls the pancreatic beta-cell potassium channel that regulates insulin se...
|
Energy & Weight
|
|
Strong
|
|
rs2943641
|
IRS1
Near-gene C>T
|
Regulates insulin signaling efficiency and cellular glucose uptake
|
Energy & Weight
|
|
Strong
|
|
rs9939609
|
FTO
Intron 1 T>A
|
The most strongly replicated obesity-associated variant, affecting body weigh...
|
Energy & Weight
|
|
Established
|
|
rs17782313
|
MC4R
Near-gene C>T
|
Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...
|
Energy & Weight
|
|
Strong
|
|
rs58542926
|
TM6SF2
E167K
|
Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...
|
Lipid & Fat Metabolism
|
|
Strong
|
|
rs1800592
|
UCP1
A-3826G
|
Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...
|
Energy & Weight
|
|
Moderate
|
|
rs7181866
|
GABPB1
|
Intronic variant in the mitochondrial biogenesis regulator NRF2, associated w...
|
Fitness & Body
|
|
Moderate
|
|
rs10166942
|
TRPM8
|
Upstream regulatory variant of the cold-sensing TRPM8 channel that modulates ...
|
Neurology & Cognition
|
|
Strong
|
|
rs29941
|
KCTD15
|
GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...
|
Energy & Weight
|
|
Moderate
|
|
rs7647305
|
ETV5
|
GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...
|
Energy & Weight
|
|
Moderate
|
|
rs10838738
|
MTCH2
|
Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance...
|
Energy & Weight
|
|
Moderate
|
|
rs1001179
|
CAT
-262C>T
|
Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...
|
Methylation & Detox
|
|
Strong
|
|
rs10938397
|
GNPDA2
|
GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...
|
Energy & Weight
|
|
Strong
|