Tag

Metabolic Syndrome

11 genetic variants with this tag.

RSID	Gene	Description	Category
rs1799941	SHBG	Promoter region variant affecting sex hormone-binding globulin levels, with t...	Hormones & Sleep	Hormones & Thyroid Cardiovascular Diabetes	Strong
rs41423247	NR3C1 BclI	Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s...	Mood & Behavior	Mental Health Stress Response Cortisol	Strong
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Energy & Weight	Obesity Appetite Metabolic Syndrome	Moderate
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension Blood Pressure Antidepressants	Strong
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	Cortisol HPA Axis Metabolic Syndrome	Moderate
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Nutrition & Metabolism Obesity Diabetes	Moderate
rs5068	NPPA	3'UTR variant that disrupts miR-425 binding, increasing atrial natriuretic pe...	Heart & Inflammation	Cardiovascular Blood Pressure Hypertension	Strong
rs10482605	NR3C1	NR3C1 promoter variant reducing glucocorticoid receptor transcription; G alle...	Longevity & Aging	Longevity Aging HPA Axis	Moderate