Tag

Triglycerides

24 genetic variants with this tag.

RSID	Gene	Description	Category
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Lipid & Fat Metabolism	Fat Metabolism Diet Obesity	Strong
rs3135506	APOA5 S19W	Triglyceride metabolism - affects fasting triglyceride levels and cardiovascu...	Lipid & Fat Metabolism	Triglycerides Cardiovascular Fat Metabolism	Strong
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; A allele c...	Heart & Inflammation	Cardiovascular Cholesterol Triglycerides	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Energy & Weight	Diabetes Insulin Cardiovascular	Strong
rs174537	FADS1	Regulatory variant in the FADS1 locus that controls delta-5 desaturase expres...	Lipid & Fat Metabolism	Omega-3 Fat Metabolism Cardiovascular	Strong
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Lipid & Fat Metabolism	HDL Cholesterol Fat Metabolism Cholesterol	Strong
rs2954021	TRIB1	Near-gene variant influencing hepatic lipid metabolism; G allele raises trigl...	Lipid & Fat Metabolism	Triglycerides Cardiovascular Cholesterol	Established
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Energy & Weight	Leptin Satiety Obesity	Moderate
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Lipid & Fat Metabolism	Triglycerides Cardiovascular Cholesterol	Strong
rs2542052	APOC3	Promoter variant that reduces APOC3 expression, associated with lower triglyc...	Longevity & Aging	Longevity Triglycerides Cardiovascular	Strong
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Heart & Inflammation	Triglycerides Cardiovascular Cholesterol	Strong
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Lipid & Fat Metabolism	Fat Metabolism Triglycerides Diet	Established
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Lipid & Fat Metabolism	Metabolic Cardiovascular Cholesterol	Strong
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Triglycerides	Strong
rs1800588	LIPC -514C>T	Promoter variant that reduces hepatic lipase activity, raising HDL-C levels b...	Heart & Inflammation	Cholesterol Fat Metabolism Cardiovascular	Strong
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Lipid & Fat Metabolism	Liver Health Fat Metabolism Cholesterol	Established
rs662799	APOA5 -1131T>C	Promoter variant that reduces APOA5 expression, impairing lipoprotein lipase ...	Heart & Inflammation	Triglycerides Fat Metabolism Cardiovascular	Strong
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Lipid & Fat Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Lipid & Fat Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs17465637	MIA3	Intronic variant in MIA3/TANGO1 affecting collagen secretion and vascular smo...	Heart & Inflammation	Cardiovascular Atherosclerosis Inflammation	Strong
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Energy & Weight	Fat Metabolism Obesity Diet	Strong
rs1800206	PPARA Leu162Val (L162V)	Missense variant in PPARA that reduces receptor transcriptional activity, ele...	Fitness & Body	Fat Metabolism Cardiovascular Omega-3	Moderate