Tag

Insulin Resistance

13 genetic variants with this tag.

RSID	Gene	Description	Category
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Energy & Weight	Leptin Satiety Obesity	Moderate
rs659366	UCP2	Promoter variant at position -866 of UCP2 that controls mitochondrial uncoupl...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs1862513	RETN -420C>G	Promoter variant that increases resistin expression via Sp1/Sp3 transcription...	Energy & Weight	Nutrition & Metabolism Insulin Resistance Inflammation	Moderate
rs8192678	PPARGC1A Gly482Ser	Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha...	Longevity & Aging	Fitness Endurance Diabetes	Strong
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	Cortisol HPA Axis Metabolic Syndrome	Moderate
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Nutrition & Metabolism Obesity Diabetes	Moderate
rs11590235	SKI	TGF-beta signaling regulator variant identified as the top shared locus betwe...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Moderate
rs9491696	RSPO3	Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt...	Energy & Weight	Fat Metabolism Obesity Insulin Resistance	Strong
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Energy & Weight	Obesity Appetite Fat Metabolism	Strong
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Energy & Weight	Obesity Metabolic Fat Metabolism	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Energy & Weight	Obesity Leptin Insulin Resistance	Strong
rs116862713	PRKAB1	Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig...	Vitamins & Micronutrients	Diabetes Insulin Resistance Energy Metabolism	Emerging