Tag

Neurotransmitters

43 genetic variants with this tag.

RSID	Gene	Description	Category
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Mood & Behavior	Dopamine Cognition Neurotransmitters	Strong
rs225014	DIO2 Thr92Ala	Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pitu...	Hormones & Sleep	Hormones & Thyroid Neurotransmitters Metabolism	Strong
rs1800955	DRD4 -521C>T	Promoter variant that modulates dopamine D4 receptor expression in the prefro...	Mood & Behavior	Cognition Dopamine Neurotransmitters	Moderate
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Longevity & Aging	Mental Health Longevity Cardiovascular	Strong
rs1611115	DBH -1021C>T	Strongest known genetic determinant of dopamine beta-hydroxylase activity, co...	Mood & Behavior	Cognition Dopamine Neurotransmitters	Strong
rs4570625	TPH2 G-703T	Promoter variant affecting brain serotonin synthesis enzyme; influences emoti...	Mood & Behavior	Mental Health Neurotransmitters Depression	Moderate
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Mood & Behavior	Mental Health Antidepressants Neurotransmitters	Moderate
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Mental Health Neurotransmitters Cardiovascular	Moderate
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Mood & Behavior	Mental Health Neurotransmitters Antidepressants	Moderate
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Mood & Behavior	Serotonin Neurotransmitters Mental Health	Moderate
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Mood & Behavior	Mental Health Neurotransmitters Mood	Strong
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Methylation Neurotransmitters Detoxification	Established
rs53576	OXTR Intronic A>G	Most-studied oxytocin receptor variant, influencing empathy, social sensitivi...	Mood & Behavior	Cognition Empathy Stress	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Energy & Weight	Obesity Appetite Diet	Moderate
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Mood & Behavior	Stress Response Appetite Obesity	Moderate
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Sleep Melatonin Circadian	Moderate
rs524952	GJD2	Intergenic variant near GJD2 affecting myopia risk and axial eye growth throu...	Skin & Eyes	Eye Health Vision Neurotransmitters	Strong
rs279858	GABRA2 K132K	GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ...	Mood & Behavior	Mental Health Alcohol Anxiety	Strong
rs5751876	ADORA2A 1976T>C	Adenosine A2A receptor variant that determines individual sensitivity to caff...	Hormones & Sleep	Sleep Caffeine Anxiety	Strong
rs324420	FAAH Pro129Thr	Affects anandamide levels through altered FAAH enzyme stability, influencing ...	Mood & Behavior	Mental Health Neurotransmitters Pain Management	Strong
rs806368	CNR1	3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio...	Mood & Behavior	Addiction Neurotransmitters Brain Health	Moderate
rs1049353	CNR1 3'UTR (G1359A)	Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp...	Mood & Behavior	Endocannabinoid Addiction Stress Response	Moderate
rs4654748	NBPF3	Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...	Vitamins & Micronutrients	B Vitamins Homocysteine Neurotransmitters	Strong
rs6454674	CNR1 Near gene (SNP3)	Intronic variant in the cannabinoid receptor 1 gene that modulates substance ...	Mood & Behavior	Addiction Endocannabinoid Neurotransmitters	Moderate
rs2023239	CNR1	Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1...	Mood & Behavior	Endocannabinoid Addiction Brain Health	Moderate
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension Blood Pressure Antidepressants	Strong
rs1050891	HNMT 3'UTR variant	Histamine breakdown in blood and tissues - uses methyl groups from SAM	Methylation & Detox	Histamine Methylation Detoxification	Moderate
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Mood & Behavior	Mental Health Addiction Smoking	Established
rs11558538	HNMT Thr105Ile	HNMT structural variant - reduces enzyme stability and histamine clearance in...	Methylation & Detox	Histamine Methylation Detoxification	Strong
rs588765	CHRNA5 5' UTR / Locus 3	Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs6746030	SCN9A R1150W	Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa...	Neurology & Cognition	Pain Sensitivity Neurotransmitters Anesthesia	Strong
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Mood & Behavior	Mental Health Addiction Smoking	Established
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Neurology & Cognition	Pain Sensitivity Neurotransmitters Cardiovascular	Strong
rs1799971	OPRM1 A118G	Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p...	Pharmacogenomics	Drug Metabolism Pain Medication Addiction	Moderate
rs578776	CHRNA3 3' UTR	CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Neurology & Cognition	Pain Sensitivity Nitric Oxide Neurotransmitters	Strong
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs6777055	CACNA2D3	Intronic variant affecting thermal pain sensitivity and central pain signal t...	Neurology & Cognition	Pain Sensitivity Neurotransmitters Sensory Processing	Moderate
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Energy & Weight	Obesity Appetite Diet	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Energy & Weight	Obesity Appetite Diabetes	Moderate
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Energy & Weight	Obesity Appetite Neurotransmitters	Strong