Tag

Brain Health

35 genetic variants with this tag.

RSID	Gene	Description	Category
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Mood & Behavior	Dopamine Cognition Neurotransmitters	Strong
rs6265	BDNF Val66Met	Key neurotrophin variant that controls activity-dependent BDNF release, affec...	Neurology & Cognition	Cognition Memory Neuroplasticity	Strong
rs17070145	WWC1 Intronic C>T	Influences episodic memory performance and hippocampal function through the K...	Neurology & Cognition	Cognition Memory Alzheimer's	Moderate
rs1800955	DRD4 -521C>T	Promoter variant that modulates dopamine D4 receptor expression in the prefro...	Mood & Behavior	Cognition Dopamine Neurotransmitters	Moderate
rs6439886	CLSTN2	Intronic variant in the calsyntenin-2 gene associated with episodic memory pe...	Neurology & Cognition	Memory Cognition Brain Health	Moderate
rs744373	BIN1	Second strongest genetic risk factor for Alzheimer's disease after APOE, asso...	Neurology & Cognition	Alzheimer's Neurological Risk Memory	Established
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Neurology & Cognition	Neurological Risk Parkinson's Neuroprotection	Strong
rs2736990	SNCA	Intronic SNCA variant (intron 4) associated with Parkinson's disease risk and...	Neurology & Cognition	Neurological Risk Parkinson's Neuroprotection	Strong
rs11931074	SNCA	SNCA 3′-region variant in the extended 3′ UTR that affects alpha-synuclein mR...	Neurology & Cognition	Neurological Risk Parkinson's Neuroprotection	Strong
rs2583988	SNCA	SNCA upstream regulatory variant (near gene-5) that is part of the 4-SNP SNCA...	Neurology & Cognition	Neurological Risk Parkinson's Neuroprotection	Emerging
rs17649553	MAPT H1/H2 Haplotype Tag	Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...	Neurology & Cognition	Neurological Risk Parkinson's Dementia	Strong
rs1800547	MAPT H1/H2 Haplotype Splice Regulator	Intronic MAPT variant that regulates tau exon 3 splicing via hnRNP F/Q bindin...	Neurology & Cognition	Neurological Risk Parkinson's Dementia	Strong
rs242557	MAPT H1c Sub-haplotype Tag	Intronic MAPT variant tagging the H1c sub-haplotype within the H1 clade, inde...	Neurology & Cognition	Neurological Risk Parkinson's Dementia	Strong
rs2471738	MAPT H1c Sub-haplotype Tag (rs2471738)	Intronic MAPT variant whose T allele co-defines the H1c sub-haplotype, indepe...	Neurology & Cognition	Neurological Risk Parkinson's Dementia	Strong
rs806368	CNR1	3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio...	Mood & Behavior	Addiction Neurotransmitters Brain Health	Moderate
rs1049353	CNR1 3'UTR (G1359A)	Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp...	Mood & Behavior	Endocannabinoid Addiction Stress Response	Moderate
rs17651213	MAPT Exon 3 Splice Regulator	Intronic MAPT variant that directly regulates tau exon 3 splicing via differe...	Neurology & Cognition	Neurological Risk Parkinson's Dementia	Strong
rs3785883	MAPT H1h Sub-haplotype Tag	Intronic MAPT variant whose A allele defines the H1h sub-haplotype — a config...	Neurology & Cognition	Neurological Risk Parkinson's Tau Pathology	Moderate
rs6454674	CNR1 Near gene (SNP3)	Intronic variant in the cannabinoid receptor 1 gene that modulates substance ...	Mood & Behavior	Addiction Endocannabinoid Neurotransmitters	Moderate
rs2023239	CNR1	Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1...	Mood & Behavior	Endocannabinoid Addiction Brain Health	Moderate
rs356219	SNCA	SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression...	Neurology & Cognition	Neurological Risk Parkinson's Neuroprotection	Strong
rs76904798	LRRK2 5' Regulatory Variant	Common noncoding variant upstream of LRRK2 that increases gene expression in ...	Neurology & Cognition	Parkinson's Neurological Risk Brain Health	Strong
rs10166942	TRPM8	Upstream regulatory variant of the cold-sensing TRPM8 channel that modulates ...	Neurology & Cognition	Brain Health Pain Sensitivity Thermogenesis	Strong
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Neurology & Cognition	Neuroinflammation Pain Sensitivity Inflammation	Moderate
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Energy & Weight	Obesity Appetite Diet	Strong
rs1006737	CACNA1C	L-type calcium channel gene variant affecting mood regulation, emotional proc...	Mood & Behavior	Mental Health Brain Health Mood	Strong
rs7958311	P2RX7 Arg270His	P2RX7 variant with a unique dual mechanism — gain-of-function in channel open...	Neurology & Cognition	Pain Sensitivity Neuroinflammation Inflammation	Moderate
rs11172113	LRP1	Intronic enhancer variant in LRP1 that regulates receptor expression in brain...	Energy & Weight	Leptin Cardiovascular Brain Health	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Neuroinflammation Mental Health Mood	Moderate
rs956572	BCL2	Intronic variant in the anti-apoptotic gene BCL2 that affects BCL2 expression...	Mood & Behavior	Brain Health Mental Health Neuroprotection	Moderate
rs2271933	HCRTR1 Ile408Val	Missense variant in the orexin/hypocretin receptor 1 that alters G-protein si...	Mood & Behavior	Migraine Mood Anxiety	Moderate
rs727503493	TMPRSS3 c.208delC (p.His70Thrfs*19)	Frameshift deletion in TMPRSS3 causing premature stop at codon 88; a severe p...	Neurology & Cognition	Hearing Loss Sensorineural Carrier Status	Strong
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Energy & Weight	Obesity Satiety Appetite	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Energy & Weight	Obesity Appetite Neurotransmitters	Strong
rs199347	GPNMB	Intronic GPNMB variant that acts as a brain eQTL; the A allele increases GPNM...	Longevity & Aging	Longevity Neuroinflammation Parkinson's	Strong