Tag

Addiction

18 genetic variants with this tag.

RSID	Gene	Description	Category
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Mood & Behavior	Dopamine Cognition Neurotransmitters	Strong
rs279858	GABRA2 K132K	GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ...	Mood & Behavior	Mental Health Alcohol Anxiety	Strong
rs324420	FAAH Pro129Thr	Affects anandamide levels through altered FAAH enzyme stability, influencing ...	Mood & Behavior	Mental Health Neurotransmitters Pain Management	Strong
rs806368	CNR1	3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio...	Mood & Behavior	Addiction Neurotransmitters Brain Health	Moderate
rs1049353	CNR1 3'UTR (G1359A)	Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp...	Mood & Behavior	Endocannabinoid Addiction Stress Response	Moderate
rs6454674	CNR1 Near gene (SNP3)	Intronic variant in the cannabinoid receptor 1 gene that modulates substance ...	Mood & Behavior	Addiction Endocannabinoid Neurotransmitters	Moderate
rs2023239	CNR1	Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1...	Mood & Behavior	Endocannabinoid Addiction Brain Health	Moderate
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Mood & Behavior	Mental Health Addiction Smoking	Established
rs588765	CHRNA5 5' UTR / Locus 3	Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Mood & Behavior	Mental Health Addiction Smoking	Established
rs1799971	OPRM1 A118G	Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p...	Pharmacogenomics	Drug Metabolism Pain Medication Addiction	Moderate
rs578776	CHRNA3 3' UTR	CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Mood & Behavior	Mental Health Addiction Smoking	Strong
rs1229984	ADH1B His48Arg	ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r...	Mood & Behavior	Addiction Alcohol Cancer Risk	Established
rs2066702	ADH1B Arg370Cys	ADH1B*3 variant encoding a superactive alcohol dehydrogenase found almost exc...	Mood & Behavior	Addiction Alcohol Detoxification	Strong
rs1693482	ADH1C Arg272Gln (ADH1C1/2)	ADH1C variant defining the fast (ADH1C1, Arg272) vs slow (ADH1C2, Gln272) a...	Mood & Behavior	Addiction Alcohol Cancer Risk	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Energy & Weight	Obesity Appetite Neurotransmitters	Strong