Tag

Neuroinflammation

15 genetic variants with this tag.

RSID	Gene	Description	Category
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Neurology & Cognition	Alzheimer's Neurological Risk Neuroinflammation	Established
rs76904798	LRRK2 5' Regulatory Variant	Common noncoding variant upstream of LRRK2 that increases gene expression in ...	Neurology & Cognition	Parkinson's Neurological Risk Brain Health	Strong
rs2069837	IL6	Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB...	Longevity & Aging	Longevity Aging Inflammation	Moderate
rs3751143	P2RX7 Glu496Ala	Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...	Neurology & Cognition	Pain Sensitivity Inflammation Immune Function	Strong
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Neurology & Cognition	Neuroinflammation Pain Sensitivity Chronic Pain	Moderate
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Neurology & Cognition	Neuroinflammation Pain Sensitivity Inflammation	Moderate
rs7958311	P2RX7 Arg270His	P2RX7 variant with a unique dual mechanism — gain-of-function in channel open...	Neurology & Cognition	Pain Sensitivity Neuroinflammation Inflammation	Moderate
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Neuroinflammation Mental Health Mood	Moderate
rs3135388	HLA-DRA Tag for DRB1*15:01	Tag SNP for HLA-DRB1*15:01 (physically located near HLA-DRA), the strongest g...	Immune & Gut	Immune & Gut Immune & Autoimmune HLA	Established
rs2300747	CD58	Intronic variant in CD58 (LFA-3) that modulates T-cell costimulation and Treg...	Immune & Gut	Immune & Gut Autoimmune Neuroinflammation	Strong
rs1800693	TNFRSF1A	Splice-region variant in TNFR1 that generates a soluble Δ6 isoform mimicking ...	Immune & Gut	Immune & Autoimmune Inflammation Drug Metabolism	Strong
rs199347	GPNMB	Intronic GPNMB variant that acts as a brain eQTL; the A allele increases GPNM...	Longevity & Aging	Longevity Neuroinflammation Parkinson's	Strong
rs4149584	TNFRSF1A R92Q	Missense variant in TNF receptor 1 that causes low-penetrance TRAPS (recurren...	Immune & Gut	Immune & Autoimmune Inflammation Neuroinflammation	Strong
rs9271366	HLA-DQA1 eQTL	Intergenic eQTL near HLA-DQA1 that tags the DR15 haplotype (DRB115:01/DQA10...	Immune & Gut	Immune & Gut Immune & Autoimmune HLA	Established
rs12044852	CD58	Intronic CD58 variant in strong LD with rs2300747 (r²=0.929); the C allele dr...	Immune & Gut	Immune & Gut Multiple Sclerosis T-Cell Regulation	Strong