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rs429358
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APOE
E4 determinant
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Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...
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Lipid & Fat Metabolism
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Established
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rs17070145
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WWC1
Intronic C>T
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Influences episodic memory performance and hippocampal function through the K...
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Neurology & Cognition
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Moderate
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rs9536314
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KLOTHO
F352V (KL-VS)
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Longevity-associated variant exhibiting overdominance where heterozygotes sho...
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Longevity & Aging
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Strong
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rs744373
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BIN1
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Second strongest genetic risk factor for Alzheimer's disease after APOE, asso...
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Neurology & Cognition
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Established
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rs11136000
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CLU
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Intronic variant in clusterin gene affecting Alzheimer's disease risk through...
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Neurology & Cognition
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Established
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rs75932628
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TREM2
R47H
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Rare missense variant in microglial receptor TREM2 that significantly increas...
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Neurology & Cognition
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Established
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rs3851179
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PICALM
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Variant in the PICALM gene affecting amyloid-beta clearance across the blood-...
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Neurology & Cognition
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Established
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rs17649553
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MAPT
H1/H2 Haplotype Tag
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Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...
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Neurology & Cognition
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Strong
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rs1800547
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MAPT
H1/H2 Haplotype Splice Regulator
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Intronic MAPT variant that regulates tau exon 3 splicing via hnRNP F/Q bindin...
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Neurology & Cognition
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Strong
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rs5882
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CETP
I405V
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Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi...
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Longevity & Aging
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Moderate
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rs2069837
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IL6
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Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB...
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Longevity & Aging
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Moderate
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rs1524107
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IL6
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Intronic IL6 variant tagging a low-producing haplotype — the T allele is prot...
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Longevity & Aging
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Moderate
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rs1937
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TFAM
S12T
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Missense variant in the TFAM mitochondrial targeting sequence — the C allele ...
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Longevity & Aging
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Moderate
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