Tag

Multiple Sclerosis

8 genetic variants with this tag.

RSID	Gene	Description	Category
rs3135388	HLA-DRA Tag for DRB1*15:01	Tag SNP for HLA-DRB1*15:01 (physically located near HLA-DRA), the strongest g...	Immune & Gut	Immune & Gut Immune & Autoimmune HLA	Established
rs6897932	IL7R T244I	A missense variant in the IL-7 receptor alpha chain that increases soluble IL...	Immune & Gut	Immune & Autoimmune Multiple Sclerosis T-Cell Regulation	Strong
rs2300747	CD58	Intronic variant in CD58 (LFA-3) that modulates T-cell costimulation and Treg...	Immune & Gut	Immune & Gut Autoimmune Neuroinflammation	Strong
rs1800693	TNFRSF1A	Splice-region variant in TNFR1 that generates a soluble Δ6 isoform mimicking ...	Immune & Gut	Immune & Autoimmune Inflammation Drug Metabolism	Strong
rs11808092	EVI5	Missense variant in EVI5's coiled-coil domain altering immune cell traffickin...	Immune & Gut	Autoimmune Immune & Autoimmune Multiple Sclerosis	Strong
rs2523506	DDX39B	Regulatory variant in the 5' UTR of DDX39B (RNA helicase/mRNA export factor) ...	Immune & Gut	Immune & Autoimmune Multiple Sclerosis RNA Splicing	Strong
rs4149584	TNFRSF1A R92Q	Missense variant in TNF receptor 1 that causes low-penetrance TRAPS (recurren...	Immune & Gut	Immune & Autoimmune Inflammation Neuroinflammation	Strong
rs12044852	CD58	Intronic CD58 variant in strong LD with rs2300747 (r²=0.929); the C allele dr...	Immune & Gut	Immune & Gut Multiple Sclerosis T-Cell Regulation	Strong