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rs12934922
|
BCO1
Arg267Ser
|
Reduces beta-carotene to retinol (vitamin A) conversion efficiency, contribut...
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Vitamins & Micronutrients
|
|
Strong
|
|
rs7834555
|
BCO1
|
Intergenic GWAS tag SNP near the BCO1 pathway, associated with circulating be...
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Vitamins & Micronutrients
|
|
Emerging
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rs6420424
|
BCO1
|
Upstream regulatory variant near BCO1 that reduces beta-carotene to vitamin A...
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Vitamins & Micronutrients
|
|
Moderate
|
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rs2052129
|
AOC1 (DAO)
promoter variant
|
Histamine breakdown in gut - reduced activity means dietary histamine accumul...
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Methylation & Detox
|
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Strong
|
|
rs10156191
|
AOC1 (DAO)
Thr16Met
|
DAO structural variant affecting enzyme activity and histamine degradation
|
Methylation & Detox
|
|
Strong
|
|
rs1049793
|
AOC1 (DAO)
His645Asp
|
DAO structural variant near the catalytic domain affecting histamine degradation
|
Methylation & Detox
|
|
Strong
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|
rs61816761
|
FLG
R501X
|
Nonsense variant eliminating filaggrin protein, the major genetic risk factor...
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Immune & Gut
|
|
Established
|
|
rs4988235
|
LCT
-13910C>T
|
Lactase persistence - ability to digest lactose (milk sugar) in adulthood
|
Methylation & Detox
|
|
Established
|
|
rs601338
|
FUT2
W143X (Trp143Ter)
|
Determines secretor status — whether ABO blood group antigens are secreted in...
|
Vitamins & Micronutrients
|
|
Established
|
|
rs558269137
|
FLG
2282del4
|
Frameshift deletion eliminating filaggrin protein, the second most common Eur...
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Immune & Gut
|
|
Established
|
|
rs12730935
|
FLG
3702delG
|
Frameshift deletion in the third filaggrin repeat domain — the third most com...
|
Immune & Gut
|
|
Established
|
|
rs372628716
|
FLG
S3247X
|
Nonsense variant eliminating filaggrin protein — a minor European FLG null al...
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Immune & Gut
|
|
Strong
|