|
rs1805007
|
MC1R
R151C
|
Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...
|
Skin & Eyes
|
|
Established
|
|
rs61816761
|
FLG
R501X
|
Nonsense variant eliminating filaggrin protein, the major genetic risk factor...
|
Immune & Gut
|
|
Established
|
|
rs3126085
|
FLG
|
Intronic regulatory variant in the filaggrin gene locus that reduces FLG expr...
|
Skin & Eyes
|
|
Strong
|
|
rs1801275
|
IL4R
Q576R
|
Gain-of-function missense variant in the IL-4 receptor alpha chain that ampli...
|
Immune & Gut
|
|
Strong
|
|
rs12191877
|
HLA-C
Tag for *06:02
|
Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det...
|
Immune & Gut
|
|
Established
|
|
rs4406273
|
HLA-C
|
Near-HLA-C intergenic variant that tags HLA-C*06:02 haplotype, conferring ris...
|
Immune & Gut
|
|
Strong
|
|
rs33980500
|
TRAF3IP2
D10N
|
Missense variant in Act1 that abolishes IL-17 signaling by disrupting TRAF6 b...
|
Immune & Gut
|
|
Strong
|
|
rs5743708
|
TLR2
R753Q
|
Missense variant in Toll-Like Receptor 2 impairing innate immune signaling to...
|
Immune & Gut
|
|
Strong
|
|
rs558269137
|
FLG
2282del4
|
Frameshift deletion eliminating filaggrin protein, the second most common Eur...
|
Immune & Gut
|
|
Established
|
|
rs12730935
|
FLG
3702delG
|
Frameshift deletion in the third filaggrin repeat domain — the third most com...
|
Immune & Gut
|
|
Established
|
|
rs372628716
|
FLG
S3247X
|
Nonsense variant eliminating filaggrin protein — a minor European FLG null al...
|
Immune & Gut
|
|
Strong
|
|
rs4696480
|
TLR2
T-16934A
|
Promoter variant in Toll-Like Receptor 2 that increases TLR2 expression, asso...
|
Immune & Gut
|
|
Moderate
|