Tag

Bone Health

17 genetic variants with this tag.

RSID	Gene	Description	Category
rs17878486	AMELX	Intronic variant in amelogenin X-linked gene affecting enamel mineralization ...	Dental & Oral Health	Dental & Oral Health Enamel Health Bone Health	Moderate
rs1537415	GLT6D1	Intronic variant in GLT6D1 reducing GATA-3 transcription factor binding in T ...	Dental & Oral Health	Dental & Oral Health Inflammation Immune System	Strong
rs700518	CYP19A1 Val80	Synonymous variant in aromatase gene affecting estrogen production, bone dens...	Hormones & Sleep	Hormones Estrogen Bone Health	Strong
rs4588	GC Thr436Lys	Alters vitamin D binding protein affinity, affecting total and bioavailable 2...	Vitamins & Micronutrients	Vitamin D Bone Health Cardiovascular	Strong
rs2234693	ESR1 PvuII	Estrogen receptor alpha intron variant affecting receptor expression and estr...	Hormones & Sleep	Hormones & Thyroid Bone Health Cardiovascular	Moderate
rs2235091	KLK4	Intronic variant in kallikrein-4 that encodes the enamel maturation protease;...	Dental & Oral Health	Dental & Oral Health Enamel Health Minerals	Moderate
rs7041	GC Asp432Glu	Vitamin D binding protein variant that determines VDBP isoform, affecting vit...	Vitamins & Micronutrients	Vitamin D Bone Health Diet	Strong
rs2282679	GC	Intronic GWAS tag variant in the vitamin D binding protein gene, the stronges...	Vitamins & Micronutrients	Vitamin D Bone Health Cardiovascular	Established
rs12785878	DHCR7 Near gene T>G	Influences vitamin D synthesis by regulating how much 7-dehydrocholesterol is...	Vitamins & Micronutrients	Vitamin D Bone Health Immune System	Strong
rs7944926	DHCR7	Near-gene intronic variant in the DHCR7/NADSYN1 locus on chromosome 11 that t...	Vitamins & Micronutrients	Vitamin D Bone Health Immune System	Strong
rs2228570	VDR FokI C>T	Vitamin D receptor start codon variant — determines receptor protein length a...	Vitamins & Micronutrients	Vitamin D Bone Health Diet	Strong
rs6013897	CYP24A1	Near-gene regulatory variant affecting vitamin D 24-hydroxylase expression — ...	Vitamins & Micronutrients	Vitamin D Bone Health Diet	Strong
rs7940244	NADSYN1 Near DHCR7	Intronic NADSYN1 variant in the DHCR7/NADSYN1 vitamin D locus; T allele tags ...	Vitamins & Micronutrients	Vitamin D Bone Health Immune System	Strong
rs3829251	NADSYN1	Intronic NADSYN1 variant at the DHCR7/NADSYN1 vitamin D locus; A allele was t...	Vitamins & Micronutrients	Vitamin D Bone Health Immune System	Strong
rs1991517	TSHR Asp727Glu	Affects TSH receptor sensitivity and thyroid hormone regulation; influences T...	Hormones & Sleep	Hormones & Thyroid Thyroid Metabolism	Strong
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	Cortisol HPA Axis Metabolic Syndrome	Moderate
rs4810485	CD40	Intronic variant in CD40 regulating B-cell surface expression; the G allele d...	Immune & Gut	Immune & Autoimmune Rheumatoid Arthritis Inflammation	Strong