Tag

Interferon

11 genetic variants with this tag.

RSID	Gene	Description	Category
rs2004640	IRF5 G198T	Intronic variant creating alternative splice site that increases type I inter...	Immune & Gut	Immune & Autoimmune Inflammation Interferon	Strong
rs1990760	IFIH1 Ala946Thr	Gain-of-function missense variant in the MDA5 viral RNA sensor, enhancing typ...	Immune & Gut	Immune & Autoimmune Type 1 Diabetes Innate Immunity	Strong
rs10488631	IRF5	Near-gene regulatory variant tagging an IRF5 haplotype that elevates interfer...	Immune & Gut	Immune & Autoimmune Interferon Lupus	Strong
rs7574865	STAT4 Intron 3	Intronic STAT4 variant that amplifies the interferon-alpha and IL-12 response...	Immune & Gut	Immune & Gut Lupus Interferon	Strong
rs12979860	IFNL4	Intronic variant in IFNL4 — the strongest host genetic predictor of hepatitis...	Immune & Gut	Innate Immunity Inflammation Infectious Disease	Established
rs368234815	IFNL4 ss469415590 (TT/ΔG)	Causal frameshift polymorphism controlling IFNL4 protein production; the ΔG a...	Immune & Gut	Immune & Antiviral Hepatitis C Interferon	Established
rs117648444	IFNL4 Pro70Ser (P70S)	Missense variant in IFNL4 exon 2 that reduces IFN-λ4 protein activity; the Se...	Immune & Gut	Immune & Antiviral Hepatitis C Interferon	Strong
rs729302	IRF5	Near-gene variant tagging an IRF5 protective haplotype in the 5' promoter reg...	Immune & Gut	Immune & Autoimmune Interferon Lupus	Strong
rs3131379	MSH5	Intronic variant in the HLA class III region near MSH5 associated with lupus ...	Immune & Gut	Immune & Autoimmune Lupus Interferon	Strong
rs8099917	IFNL3	Intergenic variant upstream of IFNL3 — second major IL28B locus predictor of ...	Immune & Gut	Innate Immunity Inflammation Infectious Disease	Established
rs4728142	IRF5 Promoter Indel Tag (CGGGG insertion)	Enhancer variant ~5 kb upstream of IRF5 that promotes ZBTB3-mediated chromati...	Immune & Gut	Immune & Autoimmune Interferon Lupus	Strong